Initiating Enrollment for Your Patient

Get Your Patient Started With the Horizon By Your Side Team

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Patient enrollment in Horizon By Your Side is easy. Download the enrollment form, complete with your patient, and submit the Patient Enrollment Form below. The Patient Enrollment Form also serves as a prescription. Please note that there is a specific HIPAA release section on the form required in order to initiate enrollment for your patient in Horizon By Your Side. Have your healthcare team work with your patient to finalize the form.

Download the enrollment form

Once your patient is enrolled, you will receive a comprehensive summary of your patient’s benefits from the Horizon By Your Side team. We will be there to provide support when your patient needs it throughout their treatment journey.

APPROVED USES and IMPORTANT SAFETY INFORMATION for BUPHENYL®
(sodium phenylbutyrate) Tablets and Powder

What is BUPHENYL?

BUPHENYL (sodium phenylbutyrate) Tablets is a prescription medicine that can be taken by mouth and BUPHENYL (sodium phenylbutyrate) Powder is a prescription medicine that can be taken by mouth or feeding tube for the long-term management of high blood levels of ammonia (hyperammonemia) caused by a condition called a urea cycle disorder (UCD).

BUPHENYL only treats high blood levels of ammonia in patients with the following enzyme deficiencies:

  • Carbamylphosphate synthetase (CPS)
  • Ornithine transcarbamylase (OTC)
  • Argininosuccinic acid synthetase (AS)

BUPHENYL can be used in Infants up to 28 days old who have a complete enzyme deficiency, and in patients 1 month of age and older who have a partial enzyme deficiency and have a history of brain damage from high blood levels of ammonia.

BUPHENYL must be used along with a low-protein diet and in some cases, dietary supplements.

BUPHENYL is not used to treat acute (severe) hyperammonemia, which is a medical emergency.

IMPORTANT SAFETY INFORMATION

What is the most important safety information I should know about BUPHENYL?

BUPHENYL may cause serious side effects, including:

Nervous system side effects (Neurotoxicity).The breakdown of BUPHENYL produces the byproduct phenylacetate (PAA), which may cause nervous system side effects.

  • sleepiness
  • weakness
  • lightheadedness
  • problems with memory
  • worsening of numbness, tingling, or burning in your hands or feet
  • change in taste
  • problems with hearing
  • confusion
  • nausea
  • headache

Who should not take BUPHENYL?

Do not take BUPHENYL if you are allergic to phenylbutyrate. Call your doctor or go to the nearest hospital emergency room if you experience an allergic reaction while taking BUPHENYL.

What should I tell my doctor before taking BUPHENYL?

Before taking BUPHENYL, tell your doctor about any medical conditions, including if you:

  • have heart failure or decreased kidney function, which may lead to retention of the sodium content of BUPHENYL with potentially serious consequences, such as worsening heart failure, high blood pressure, and swelling.
  • are pregnant or plan to become pregnant. It is not known if BUPHENYL will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if BUPHENYL passes into your breast milk. Breastfeeding is not recommended during treatment with BUPHENYL. Talk to your doctor about the best way to feed your baby if you take BUPHENYL.

What are possible side effects of BUPHENYL?

BUPHENYL may cause serious side effects, including:

See What is the most important safety information I should know about BUPHENYL?

The most common side effects of BUPHENYL include:

  • decreased appetite
  • body odor
  • bad taste
  • absent or irregular periods in women

These are not all of the possible side effects of BUPHENYL. Call your doctor for medical advice about side effects.

For additional important safety information, click here for the Full Prescribing Information and Patient Package Insert and discuss with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

APPROVED USES and IMPORTANT SAFETY INFORMATION for BUPHENYL®
(sodium phenylbutyrate) Tablets and Powder

What is BUPHENYL?

BUPHENYL (sodium phenylbutyrate) Tablets is a prescription medicine that can be taken by mouth and BUPHENYL (sodium phenylbutyrate) Powder is a prescription medicine that can be taken by mouth or feeding tube for the long-term management of high blood levels of ammonia (hyperammonemia) caused by a condition called a urea cycle disorder (UCD).

BUPHENYL only treats high blood levels of ammonia in patients with the following enzyme deficiencies:

  • Carbamylphosphate synthetase (CPS)
  • Ornithine transcarbamylase (OTC)
  • Argininosuccinic acid synthetase (AS)

BUPHENYL can be used in Infants up to 28 days old who have a complete enzyme deficiency, and in patients 1 month of age and older who have a partial enzyme deficiency and have a history of brain damage from high blood levels of ammonia.

BUPHENYL must be used along with a low-protein diet and in some cases, dietary supplements.

BUPHENYL is not used to treat acute (severe) hyperammonemia, which is a medical emergency.

IMPORTANT SAFETY INFORMATION

What is the most important safety information I should know about BUPHENYL?

BUPHENYL may cause serious side effects, including:

Nervous system side effects (Neurotoxicity).The breakdown of BUPHENYL produces the byproduct phenylacetate (PAA), which may cause nervous system side effects.

  • sleepiness
  • weakness
  • lightheadedness
  • problems with memory
  • worsening of numbness, tingling, or burning in your hands or feet
  • change in taste
  • problems with hearing
  • confusion
  • nausea
  • headache

Who should not take BUPHENYL?

Do not take BUPHENYL if you are allergic to phenylbutyrate. Call your doctor or go to the nearest hospital emergency room if you experience an allergic reaction while taking BUPHENYL.

What should I tell my doctor before taking BUPHENYL?

Before taking BUPHENYL, tell your doctor about any medical conditions, including if you:

  • have heart failure or decreased kidney function, which may lead to retention of the sodium content of BUPHENYL with potentially serious consequences, such as worsening heart failure, high blood pressure, and swelling.
  • are pregnant or plan to become pregnant. It is not known if BUPHENYL will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if BUPHENYL passes into your breast milk. Breastfeeding is not recommended during treatment with BUPHENYL. Talk to your doctor about the best way to feed your baby if you take BUPHENYL.

What are possible side effects of BUPHENYL?

BUPHENYL may cause serious side effects, including:

See What is the most important safety information I should know about BUPHENYL?

The most common side effects of BUPHENYL include:

  • decreased appetite
  • body odor
  • bad taste
  • absent or irregular periods in women

These are not all of the possible side effects of BUPHENYL. Call your doctor for medical advice about side effects.

For additional important safety information, click here for the Full Prescribing Information and Patient Package Insert and discuss with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.