Personalized Support for Your Patient and
Their Caregivers

Horizon By Your Side is a patient support program with dedicated team members who take a personalized approach to meeting the unique needs of every patient who is prescribed BUPHENYL® (sodium phenylbutyrate) Tablets or Powder. We will be by your patient’s side. Now that you’ve determined that BUPHENYL® (sodium phenylbutyrate) Tablets or Powder is appropriate for your patient, they have access to Horizon By Your Side, a patient support program that offers a wide range of services at no cost to help your patient reach their goals for treatment.

Whether your patient needs personal support, insurance and financial assistance, or helpful resources, the Horizon By Your Side team is here to help your patient throughout their treatment journey.

The Horizon By Your Side Team Provides Support Your Patient Can Count On

Patient Access Liaison

Patient Access Manager Patient Access Manager

Starting a new medication or treatment often comes with a lot of questions. Once enrolled, a Patient Access Liaison (PAL) is assigned to your patient. The PAL provides dedicated, one-on-one support for your patient. They work directly with individual patients to answer non-medical, logistical questions and provide support upon enrollment. Additionally, the PAL educates about navigating insurance processes and accessing treatment on your patient’s behalf. The PAL has the expertise and tools to support the patient by educating on patient benefits, prior authorization requirements, payer policies and coding and claim submissions.

The Patient Access Liaison can help your patient:

  • Receive non-medical, educational support
  • Avoid surprises at the start of treatment by talking about what to expect
  • Determine how treatment can fit into their routine
  • Understand financial assistance options
  • Learn about the insurance process
  • Obtain educational resources
  • Coordinate delivery with the specialty pharmacy to schedule shipments of their medicine
  • Receive refill reminders to help them stay on BUPHENYL as you prescribed
  • Connect with other patients living with a urea cycle disorder (UCD) through live or virtual events, peer mentor programs, and online resources

Photo of a Horizon Patient Access LiaisonPhoto of a Horizon Patient Access LiaisonPhoto of a Horizon Patient Access Liaison

Molly, Patient Access Liaison

Your patient will receive a welcome call from a Patient Access Liaison upon receipt of the enrollment form. Once your patient is enrolled, they can call, text, or email the Patient Access Liaison whenever they need non-medical, logistical support.

Case Manager

Case Manager Case Manager

For patients on BUPHENYL, the Horizon By Your Side team includes Case Managers. A Case Manager will be assigned to your patient and may also be in touch with your office to make sure important insurance information is properly shared. These comprehensive services are free of charge for your patients. In addition, a Case Manager:

  • Has the expertise and tools to educate on patient benefits, specialty pharmacy options, prior authorization requirements, and payer policies
  • Works closely with specialty pharmacies to ensure all required information is received for the timely delivery of Horizon products to your patients

APPROVED USES and IMPORTANT SAFETY INFORMATION for BUPHENYL®
(sodium phenylbutyrate) Tablets and Powder

What is BUPHENYL?

BUPHENYL (sodium phenylbutyrate) Tablets is a prescription medicine that can be taken by mouth and BUPHENYL (sodium phenylbutyrate) Powder is a prescription medicine that can be taken by mouth or feeding tube for the long-term management of high blood levels of ammonia (hyperammonemia) caused by a condition called a urea cycle disorder (UCD).

BUPHENYL only treats high blood levels of ammonia in patients with the following enzyme deficiencies:

  • Carbamylphosphate synthetase (CPS)
  • Ornithine transcarbamylase (OTC)
  • Argininosuccinic acid synthetase (AS)

BUPHENYL can be used in Infants up to 28 days old who have a complete enzyme deficiency, and in patients 1 month of age and older who have a partial enzyme deficiency and have a history of brain damage from high blood levels of ammonia.

BUPHENYL must be used along with a low-protein diet and in some cases, dietary supplements.

BUPHENYL is not used to treat acute (severe) hyperammonemia, which is a medical emergency.

IMPORTANT SAFETY INFORMATION

What is the most important safety information I should know about BUPHENYL?

BUPHENYL may cause serious side effects, including:

Nervous system side effects (Neurotoxicity).The breakdown of BUPHENYL produces the byproduct phenylacetate (PAA), which may cause nervous system side effects.

  • sleepiness
  • weakness
  • lightheadedness
  • problems with memory
  • worsening of numbness, tingling, or burning in your hands or feet
  • change in taste
  • problems with hearing
  • confusion
  • nausea
  • headache

Who should not take BUPHENYL?

Do not take BUPHENYL if you are allergic to phenylbutyrate. Call your doctor or go to the nearest hospital emergency room if you experience an allergic reaction while taking BUPHENYL.

What should I tell my doctor before taking BUPHENYL?

Before taking BUPHENYL, tell your doctor about any medical conditions, including if you:

  • have heart failure or decreased kidney function, which may lead to retention of the sodium content of BUPHENYL with potentially serious consequences, such as worsening heart failure, high blood pressure, and swelling.
  • are pregnant or plan to become pregnant. It is not known if BUPHENYL will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if BUPHENYL passes into your breast milk. Breastfeeding is not recommended during treatment with BUPHENYL. Talk to your doctor about the best way to feed your baby if you take BUPHENYL.

What are possible side effects of BUPHENYL?

BUPHENYL may cause serious side effects, including:

See What is the most important safety information I should know about BUPHENYL?

The most common side effects of BUPHENYL include:

  • decreased appetite
  • body odor
  • bad taste
  • absent or irregular periods in women

These are not all of the possible side effects of BUPHENYL. Call your doctor for medical advice about side effects.

For additional important safety information, click here for the Full Prescribing Information and Patient Package Insert and discuss with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

APPROVED USES and IMPORTANT SAFETY INFORMATION for BUPHENYL®
(sodium phenylbutyrate) Tablets and Powder

What is BUPHENYL?

BUPHENYL (sodium phenylbutyrate) Tablets is a prescription medicine that can be taken by mouth and BUPHENYL (sodium phenylbutyrate) Powder is a prescription medicine that can be taken by mouth or feeding tube for the long-term management of high blood levels of ammonia (hyperammonemia) caused by a condition called a urea cycle disorder (UCD).

BUPHENYL only treats high blood levels of ammonia in patients with the following enzyme deficiencies:

  • Carbamylphosphate synthetase (CPS)
  • Ornithine transcarbamylase (OTC)
  • Argininosuccinic acid synthetase (AS)

BUPHENYL can be used in Infants up to 28 days old who have a complete enzyme deficiency, and in patients 1 month of age and older who have a partial enzyme deficiency and have a history of brain damage from high blood levels of ammonia.

BUPHENYL must be used along with a low-protein diet and in some cases, dietary supplements.

BUPHENYL is not used to treat acute (severe) hyperammonemia, which is a medical emergency.

IMPORTANT SAFETY INFORMATION

What is the most important safety information I should know about BUPHENYL?

BUPHENYL may cause serious side effects, including:

Nervous system side effects (Neurotoxicity).The breakdown of BUPHENYL produces the byproduct phenylacetate (PAA), which may cause nervous system side effects.

  • sleepiness
  • weakness
  • lightheadedness
  • problems with memory
  • worsening of numbness, tingling, or burning in your hands or feet
  • change in taste
  • problems with hearing
  • confusion
  • nausea
  • headache

Who should not take BUPHENYL?

Do not take BUPHENYL if you are allergic to phenylbutyrate. Call your doctor or go to the nearest hospital emergency room if you experience an allergic reaction while taking BUPHENYL.

What should I tell my doctor before taking BUPHENYL?

Before taking BUPHENYL, tell your doctor about any medical conditions, including if you:

  • have heart failure or decreased kidney function, which may lead to retention of the sodium content of BUPHENYL with potentially serious consequences, such as worsening heart failure, high blood pressure, and swelling.
  • are pregnant or plan to become pregnant. It is not known if BUPHENYL will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if BUPHENYL passes into your breast milk. Breastfeeding is not recommended during treatment with BUPHENYL. Talk to your doctor about the best way to feed your baby if you take BUPHENYL.

What are possible side effects of BUPHENYL?

BUPHENYL may cause serious side effects, including:

See What is the most important safety information I should know about BUPHENYL?

The most common side effects of BUPHENYL include:

  • decreased appetite
  • body odor
  • bad taste
  • absent or irregular periods in women

These are not all of the possible side effects of BUPHENYL. Call your doctor for medical advice about side effects.

For additional important safety information, click here for the Full Prescribing Information and Patient Package Insert and discuss with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.